The Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3
(NLRP3), a member of the nucleotide-binding oligomerization domain (NOD) like receptors …

Introduction Hidradenitis suppurativa (HS) is an autoinflammatory skin disease with a high
unmet need for effective medical management. Clinically, it is characterized by inflammatory …

Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by chronic
synovitis and the progressive destruction of cartilage and bone. RA is commonly …

Background Liver fibrosis is a reversible wound-healing response that can lead to end-stage
liver diseases without effective treatment, in which HBV infection is a major cause. However …

Urticaria is an inflammatory skin disorder that may occur in isolation or associated with
angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth …

NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition
receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns …

abstract Background: Schnitzler syndrome is a rare disorder with chronic urticaria, and there
is no report summarizing the current status in Japan. Methods: A nationwide survey of major …

Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host
immune response to infection. Immune response induced by sepsis is complex and …

The majority of approved therapies for many diseases are developed to target their
underlying pathophysiology. Understanding disease pathophysiology has thus proven vital …