Abstract Objective Activated factor X (FXa) plays a key role in the coagulation cascade,
whereas accumulating evidence suggests that it also contributes to the pathophysiology of …

Calcium supplementation, particularly with vitamin D, has been an approved public health
intervention to reduce fracture risk. Enthusiasm for this intervention has been mitigated by …

Thrombin is a multifunctional serine protease produced from prothrombin, and is a key
regulator in hemostatic and non‐hemostatic processes. It is the main effector protease in …

Vitamin K-antagonists (VKA) are the most widely used anti-thrombotic drugs with substantial
efficacy in reducing risk of arterial and venous thrombosis. Several lines of evidence …

Fibrinogen is an abundant plasma protein that, when converted to fibrin by thrombin,
provides the main building blocks for the clot. Dys‐, a‐, and hypo‐fibrinogenemias have …

Atherothrombotic diseases are still major causes of inability and mortality and fighting
atherothrombosis remains a public health priority. The involvement of repeated intraplaque …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

Objective—Cardiovascular disease (CVD), the most common morbidity resulting from
atherosclerosis, remains a frequent cause of death. Efforts to develop effective therapeutic …

The concept of platelets as important players in the process of atherogenesis has become
increasingly accepted due to accumulating experimental and clinical evidence. Despite the …

Factor Xa and thrombin are well-known components of the coagulation cascade and have
been proven to be viable targets for effective anticoagulation treatment. However …