Background Activation of blood coagulation and fibrinolysis may be associated with
increased risk of coronary heart disease. We aimed to assess associations of circulating …

Background Bleeding negatively impacts quality of life in patients with unresectable
advanced gastric cancer and has the potential to be lethal. When blood transfusion and …

Cardiovascular disease is the leading determinant of mortality and morbidity in women.
Functional foods are attracting interest as potential regulators of the susceptibility to disease …

Vitamin K-antagonists (VKA) are the most widely used anticoagulant drugs to treat patients
at risk of arterial and venous thrombosis for the past 50 years. Due to unfavorable …

Red blood cells (RBCs) and platelets contribute to the coagulation capacity in bleeding and
thrombotic disorders. The thrombin generation (TG) process is considered to reflect the …

Background Hypercoagulability is a major cancer-associated complication linked to poor
patient prognosis. The production of neutrophil extracellular traps (NETs) is increasingly …

Abstract Essentials• A State of the Art lecture “Clotting factors and atherothrombosis” was
presented at the ISTH congress 2017.• Coagulation proteins are not only involved in …

Peripheral artery disease (PAD) is a major health problem with increased cardiovascular
mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation …

The biochemical characterisation of the proteolytic pathways that constitute blood
coagulation was one of the most relevant achievements in biomedical research during the …

Thrombin is a key enzyme in hemostasis and thrombosis, regulating pro-and anticoagulant
reactions by interacting with other coagulation proteins and cellular receptors. 1 Thrombin …