Although the link between blood coagulation and atherogenesis has been long postulated,
only recently, and through the extensive work on transgenic mice, crossbred on an …

Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary
syndrome and ischemic strokes. Inhibition of thrombosis is one of the important tasks …

The vascular endothelium is a multifunctional cellular system which directly influences blood
components and cells within the vessel wall in a given tissue. Importantly, this cellular …

Background Antiplatelet therapy is the standard treatment for the prevention of
cardiovascular events (CVEs). High on‐treatment platelet reactivity (HPR) is a risk factor for …

Despite improved diagnosis and treatment options, coronary artery disease (CAD) is still the
leading cause of mortality and morbidity worldwide. Established risk factors such as …

Background: The coagulation system is closely linked with vascular inflammation, although
the underlying mechanisms are still obscure. Recent studies show that protease-activated …

For many years, the attention on tissue factor (TF) in human pathophysiology has been
limited to its role as initiator of extrinsic coagulation pathway. Moreover, it was described as …

Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation,
which is dictated by the high-shear flow conditions in the artery. In this overview, we …

Background: Smoking is a major cause of morbidity and mortality. Smoking-related
epigenetic biomarkers may open new avenues to better quantify the adverse health effects …

The role of blood cholesterol levels in coronary heart disease (CHD) and the true effect of
cholesterol-lowering statin drugs are debatable. In particular, whether statins actually …