Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

This volume of Periodontology 2000 represents the 25th anniversary of the Journal, and
uses the occasion to assess important advancements in periodontology over the past …

The nexus between periodontal inflammation and the polymicrobial biofilm in the gingival
sulcus is critical to understanding the pathobiology of periodontitis. Both play a major role in …

Periodontitis is one of the most common dental diseases. Compared with healthy
periodontal tissues, the immune microenvironment plays the key role in periodontitis by …

Periodontitis has been independently associated with the chronic noncommunicable
diseases that most frequently lead to death worldwide. The aim of the present systematic …

Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell
RNA-seq experiments have provided new insight into how resident cells and infiltrating …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Periodontal diseases are caused by microbial infection and the recruitment of destructive
immune cells. Current therapies mainly deal with bacteria elimination, but the regeneration …