Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

This review examines the 'Quiet Embryo Hypothesis' which proposes that viable
preimplantation embryos operate at metabolite or nutrient turnover rates distributed within …

Genomic instability is a characteristic of most cancer cells. It is an increased tendency of
genome alteration during cell division. Cancer frequently results from damage to multiple …

Infertility represents a major clinical problem and 50% of cases are attributable to the male
partner. Testicular function is temperature dependent, and in both man and mouse the …

BACKGROUND Repeated implantation failure (RIF) is a major problem encountered in IVF.
We have previously reported that RIF-IVF patients have a different endometrial gene …

Aneuploidies are prevalent in the human embryo and impair proper development, leading to
cell cycle arrest. Recent advances in imaging and molecular and genetic analyses are …

Fecundity is the capacity to produce offspring. Identifying dietary factors that influence
human fecundity is of major clinical and public health significance. This review focuses on …

The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular
systems for studying phenotypic effects of genetic perturbations. However, with this …

The mechanisms underlying the neurotoxicity of fluorosis still remain obscure. To investigate
DNA damage, cell-cycle distribution and expression of nuclear factor kappa B (NF-κB) …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …