Health and wellness have become a cultural focus in Western countries, with weight-
management highlighted as imperative for wellbeing. This focus is clearly represented on …

Despite the wealth of epidemiological and experimental studies indicating the protective role
of regular physical activity/exercise training against the sequels of aging and cardiovascular …

Current guidelines recommend that" overweight" and" obese" individuals lose weight
through engaging in lifestyle modification involving diet, exercise and other behavior …

During aging there is an increasing imbalance of energy intake and expenditure resulting in
obesity, frailty, and metabolic disorders. For decades, research has shown that caloric …

Irisin, as a new hormone‐like myokine, is discovered in the presence of exercise‐induced
peroxisome proliferator‐activated receptor gamma coactivator‐1‐alpha (PGC‐1α). Which …

Major depressive disorder (MDD), schizophrenia (SCH), Alzheimer's disease (AD), and
Parkinson's disease (PD) are devastating neurological disorders, which increasingly …

BACKGROUND: Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic
studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 …

Humans are not programmed to be inactive. The combination of both accelerated sedentary
lifestyle and constant food availability disturbs ancient metabolic processes leading to …

Obesity is characterized by the accumulation of excess body fat and can be conceptualized
as the physical manifestation of chronic energy excess. An important challenge of today's …

Accumulating evidence indicates integration of dopamine function with metabolic signals,
highlighting a potential role for dopamine in energy balance, frequently construed as …