Psychotropic medication efficacy and tolerability are critical treatment issues faced by
individuals with psychiatric disorders and their healthcare providers. For some people, it can …

Tacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ
transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 …

Background: Pharmacogenomic testing to identify variations in genes that influence
metabolism of antidepressant medications can enhance efficacy and reduce adverse effects …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus and a comprehensive summary of structural …

Abstract Background and Objective Escitalopram and sertraline are commonly prescribed
for anxiety and depressive disorders in children and adolescents. The pharmacokinetics …

Pharmacogenomics (PGx) is considered an emergent field in developing countries.
Research on PGx in the Latin American and the Caribbean (LAC) region remains scarce …

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used
psychopharmaceutical treatment for major depressive disorder (MDD), but individual …

A novel haplotype composed of two non‐coding variants, CYP2C18 NM_000772. 3: c.* 31T
(rs2860840) and NM_000772. 2: c. 819+ 2182G (rs11188059), referred to as “CYP2C: TG,” …

Background: Adverse drug reactions (ADRs) are a significant cause of mortality, and
pharmacogenomics (PGx) offers the potential to optimize therapeutic efficacy while …

Variability in hepatic cytochrome P450 (CYP) enzymes such as 2C19 and 2D6 may
influence side-effect and efficacy outcomes for antipsychotics. Aripiprazole and risperidone …