Appraisal of evidence reliability and applicability of Paxlovid as treatment for SARS‐COV‐2 infection: A systematic review

C Zhu, JY Yin, X Chen, M Liu… - Reviews in Medical …, 2023 - Wiley Online Library
This study aimed to clarify the beneficial effect and the clinical application value of Paxlovid
in the treatment of coronavirus disease‐19 (COVID‐19) through a systematic review …

Comparative investigation on interaction between potent antimalarials and human serum albumin using multispectroscopic and computational approaches

K Azeem, M Ahmed, A Uddin, S Singh, R Patel… - …, 2023 - Wiley Online Library
This study performed a comparative investigation to explore the interaction mechanisms
between two potential antimalarial compounds, JMI 346 and JMI 105, and human serum …

Exploring the inhibition mechanism of SARS‐CoV‐2 main protease by ebselen: A molecular docking, molecular dynamics simulation and DFT approach

W You, Y Chen - Journal of Computational Chemistry, 2023 - Wiley Online Library
The main protease (Mpro) of SARS‐CoV‐2 plays an essential role in the virus life cycle and
is considered a key target for therapeutic development. This study explores the inhibition …

Comparative study of the unbinding process of some HTLV-1 protease inhibitors using unbiased molecular dynamics simulations

FN Tiyoula, H Aryapour, MJ Moghadam - Plos one, 2022 - journals.plos.org
The HTLV-1 protease is one of the major antiviral targets to overwhelm this virus. Several
research groups have developed protease inhibitors, but none has been successful. In this …