Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by
chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have …

Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for
asthma. Airway shortening occurs through calcium-dependent activation of myosin light …

Abstract The small GTPase Rho and its effector Rho-kinase (ROCK) are activated in the
diabetic kidney, and recent studies decade have demonstrated that ROCK signaling is an …

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a …

Background: Diabetes mellitus (DM) is a recognized risk factor for dementia. Because DM is
a potentially modifiable condition, greater understanding of the mechanisms linking DM to …

Abstract Ethnopharmacological relevance Cyclocarya paliurus (Batal.) Iljinskaja.(C.
paliurus) is a distinctive traditional Chinese herb, with remarkable hypoglycemic capacity …

Background Patients with type 2 diabetes mellitus (T2DM) are susceptible to coexisted with
chronic kidney disease (CKD), which may increase cardiovascular mortality in these …

Interstitial cystitis (IC), also called painful bladder syndrome (PBS), is 2 to 5 times more
common in women than in men, yet its cause and pathogenesis remain unclear. In our study …

Rho-associated coiled-coil containing kinases (ROCKs) have emerged as pivotal
downstream effectors of small guanosine triphosphatases. In recent years, isoquinoline …