Diagnosis of human immunodeficiency virus infection
BS Parekh, CY Ou, PN Fonjungo… - Clinical microbiology …, 2018 - Am Soc Microbiol
SUMMARY HIV diagnostics have played a central role in the remarkable progress in
identifying, staging, initiating, and monitoring infected individuals on life-saving antiretroviral …
identifying, staging, initiating, and monitoring infected individuals on life-saving antiretroviral …
Deep sequencing: becoming a critical tool in clinical virology
ME Quiñones-Mateu, S Avila, G Reyes-Teran… - Journal of clinical …, 2014 - Elsevier
Population (Sanger) sequencing has been the standard method in basic and clinical DNA
sequencing for almost 40 years; however, next-generation (deep) sequencing …
sequencing for almost 40 years; however, next-generation (deep) sequencing …
Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study
Plasmodium falciparum parasites that are resistant to artemisinins have been detected in
Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13 …
Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13 …
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
CD Orrú, J Yuan, BS Appleby, B Li, Y Li… - Science translational …, 2017 - science.org
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
Genetic barrier to resistance for dolutegravir.
Dolutegravir is a novel integrase strand-transfer inhibitor that displays potent in vitro activity
and a remarkably different resistance profile. Its robust pharmacokinetic/pharmacodynamic …
and a remarkably different resistance profile. Its robust pharmacokinetic/pharmacodynamic …
[HTML][HTML] Next-generation sequencing for HIV drug resistance testing: laboratory, clinical, and implementation considerations
Higher accessibility and decreasing costs of next generation sequencing (NGS), availability
of commercial kits, and development of dedicated analysis pipelines, have allowed an …
of commercial kits, and development of dedicated analysis pipelines, have allowed an …
[HTML][HTML] Performance comparison of next generation sequencing analysis pipelines for HIV-1 drug resistance testing
ER Lee, N Parkin, C Jennings, CJ Brumme, E Enns… - Scientific Reports, 2020 - nature.com
Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …
Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver
Studying the evolution of viruses and their molecular epidemiology relies on accurate viral
sequence data, so that small differences between similar viruses can be meaningfully …
sequence data, so that small differences between similar viruses can be meaningfully …
High-throughput sequencing (HTS) for the analysis of viral populations
Abstract The development of High-Throughput Sequencing (HTS) technologies is having a
major impact on the genomic analysis of viral populations. Current HTS platforms can …
major impact on the genomic analysis of viral populations. Current HTS platforms can …
Low-abundance drug-resistant HIV-1 variants in antiretroviral drug-naive individuals: a systematic review of detection methods, prevalence, and clinical impact
Background The presence of high-abundance drug-resistant HIV-1 jeopardizes success of
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …
antiretroviral therapy (ART). Despite numerous investigations, the clinical impact of low …