Objective: To revise the “Clinical Practice Guidelines for the Sustained Use of Sedatives and
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods …

Patients who are critically ill and on mechanical ventilation frequently require sedation and
analgesic therapy to optimize patient comfort, facilitate patient-ventilator synchrony, and …

As most critically ill or injured patients will require some degree of sedation, the goal of this
paper was to comprehensively review the literature associated with use of sedative agents …

Background Delirium evaluation in patients in the ICU requires the use of an
arousal/sedation assessment tool prior to assessing consciousness. The Richmond …

What is known and objective Many critically ill patients are exposed to opioids and
benzodiazepines at high doses for prolonged periods, and upon discontinuation of these …

Background Facial expression is often used to evaluate pain in noncommunicative critically
ill patients. Objectives To describe facial behavior during endotracheal suctioning …

Objective: To describe and analyze the development and psychometric properties of
subjective sedation scales developed for critically ill adult patients. Data Sources: PubMed …

The pharmacology of oversedation in mechanically ventilated... : Current Opinion in Critical
Care The pharmacology of oversedation in mechanically ventilated adults : Current Opinion in …

Optimal management of patient comfort and sedative drug therapy for intensive care unit
(ICU) patients includes establishing a goal of therapy—often defined by a desired level of …

Neurocognitive dysfunction is common in survivors of intensive care. Prolonged sedation
has been implicated but the mechanisms are unclear. Neurogenesis continues into …