Importance Observational (nonexperimental) studies that aim to emulate a randomized trial
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …

Diagnostic and therapeutic advances during the past decades have substantially improved
health outcomes for patients with acute coronary syndrome. Both age-related physiological …

Importance To our knowledge, no randomized clinical trial has compared the invasive and
conservative strategies in frail, older patients with non–ST-segment elevation acute …

Coronary artery disease (CAD) is highly prevalent in older adults, yet its management
remains challenging. Treatment choices are made complex by the frailty burden of older …

3 Shanmugam VB, Harper R, Meredith I, Malaiapan Y, Psaltis PJ. An overview of PCI in the
very elderly. J Geriatr Cardiol 2015; 12: 174–84. 4 Kaura A, Sterne JAC, Trickey A, et al …

The first international guidance on antithrombotic therapy in the elderly came from the
European Society of Cardiology Working Group on Thrombosis in 2015. This same group …

Owing to recent advances in early reperfusion strategies, pharmacological therapy,
standardized care, and the identification of vulnerable patient subsets, the prognosis of …

An acute coronary syndrome (ACS) is caused by coronary plaque rupture/erosion and
thrombus formation leading to obstruction of blood flow and distal myocardial ischemia. 1, 2 …

Background There is limited evidence on the use of high-sensitivity C-reactive protein
(hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in …

Background: On March 11, 2020, the World Health Organization declared SARS-CoV-2,
causing COVID-19, as a pandemic. The UK mass vaccination program commenced on …