A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging

C Fan, J Gao, Y Gao, X Yang, G Li, X Wang, F Li… - Chinese Chemical …, 2024 - Elsevier
As a hydrolase, chymotrypsin (CHT) is involved in many physiological activities, and its
abnormal activity is closely related to diabetes, pancreatic fibrosis, chronic pancreatitis and …

In silico identification of 20S proteasome-β5 subunit inhibitors using structure-based virtual screening

OM El Yaagoubi, W Ezzemani, L Oularbi… - Journal of …, 2023 - Taylor & Francis
Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce
apoptosis by interfering with the degradation of cell cycle proteins. 20S Proteasome is …