Familial adenomatous polyposis (FAP) is characterized by the development of many tens to
thousands of adenomas in the rectum and colon during the second decade of life. FAP has …

Although inflammation has long been known as a localized protective reaction of tissue to
irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Extensive research within the last half a century has revealed that cancer is caused by
dysregulation of as many as 500 different gene products. Most natural products target …

Lung cancer is the most common cancer, with dismal outcome. Treatment approaches,
including cisplatin-based chemotherapy and surgery, are currently based on the clinical …

BACKGROUND & AIMS: During tumorigenesis, loss of rapid messenger RNA (mRNA)
decay allows for overexpression of cancer-associated genes. The RNA-binding proteins Hu …

Expression of mutant proteins or viral infection may interfere with proper protein folding
activity in the endoplasmic reticulum (ER). Several pathways that maintain cellular …

Abstract Background and Aims: Metabolic syndrome and insulin resistance are associated
with a higher risk of colon cancer. Non‐alcoholic fatty liver disease (NAFLD) is regarded as …

Background: Colorectal carcinoma (CRC) is the most common neoplasm of the
gastrointestinal tract. COX-2 plays an important role in CRC development and is a key target …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …