Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have
been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated …

CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers
associated with human diseases. This is achieved through the binding of guide RNAs to a …

Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …

Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …