[PDF][PDF] Gene expression in patient-derived neural progenitors provide insights into neurodevelopmental aspects of schizophrenia

OV Evgrafov, C Armoskus, BB Wrobel… - …, 2017 - pdfs.semanticscholar.org
Abstract The PGC2 schizophrenia (SCZ) GWAS shows that variation in non-coding regions
is responsible for most of the common variation heritability of the disease, suggesting risk …

Akt/mTOR 信号通路活化: 脓毒症海马神经元长期丢失的潜在反应

J Guo, L Tian, W Liu, J Mu, D Zhou - 中国神经再生研究(英文版), 2017 - sjzsyj.com.cn
脓毒症幸存者易存在慢性认知功能障碍, 而海马神经元缺失与认知功能损害有关,
但其具体机制尚不可知. 试验以盲肠结扎穿孔方法诱导构建脓毒症小鼠模型, 结果发现造模后14 …

Refinement of Marble Burying Test to Model Behavioral and Neuropsychiatric Symptoms: Studies in Two Animal Models

ME Santana Santana - 2022 - ddd.uab.cat
Marble Burying Test (MB) is a commonly used in neuroscience to assess burying behavior
in rodents. Initially, this test was pharmacologically validated for its use to measure anxiety …

TDP-43 KNOCKDOWN IN MOUSE MODEL OF ALS LEADS TO DSRNA DEPOSITION, ASTROGLIOSIS, IMMUNE ACTIVATION, AND NEURODEGENERATION IN …

R Milstead, C Link, Z Xu, C Hoeffer - MOLECULAR SIGNALING AND … - search.proquest.com
RNA binding protein associated with severe neurodegenerative diseases like amyotrophic
lateral sclerosis (ALS), which primarily affects motor neurons in the brain and spinal cord …

[PDF][PDF] INSULIN RESISTANCE RELATED SIGNALING PATHWAYS IN THE LIVER

Y Wang - 2020 - jscholarship.library.jhu.edu
Over the past 20 years, the worldwide toll of diabetes has tripled to more than 400 million,
which makes it one of the fastest-growing health challenges of the 21st century. There are …

[图书][B] Abnormalities in the AKT-mTOR Signaling Pathway in the Dorsolateral Prefrontal Cortex in Schizophrenia

R Chadha - 2020 - search.proquest.com
Schizophrenia (SZ) is a complex and heterogeneous mental illness in which myriad
changes across multiple neurotransmitter systems (dopamine, serotonin, GABA, glutamate …

Avaliação do padrão de produção de mediadores inflamatórios após modulação da via PI3K/GSK3/mTOR em células mononucleares do sangue periférico de …

VT da Silveira Anício - 2019 - repositorio.ufmg.br
Introdução: A esquizofrenia é um transtorno mental grave e crônico que afeta cerca de 1%
da população e possui importante impacto nos campos da percepção, afeto e pensamento …

[PDF][PDF] Étude de l'apprentissage d'une tâche motrice: implication de la voie Akt-GSK-3

B Ouimet - 2018 - depot-e.uqtr.ca
Résumé La production des mouvements chez l'humain, et également chez plusieurs autres
mammifères, s' exécute naturellement lors de la réalisation d'une tâche motrice complexe …

[图书][B] The Development of an Inducible Akt as a Potential Gene Therapy for Parkinson's Disease

S Park - 2017 - search.proquest.com
Parkinson's disease remains a major neurodegenerative disease with prevalence that is
second only to Alzheimer's disease. Despite much advancement in the understanding of the …