Multidrug efflux pumps: structure, function and regulation
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …
throughout the world and threaten to become untreatable. The origins of resistance are …
Sequencing-based methods and resources to study antimicrobial resistance
Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …
[HTML][HTML] Antibiotics for cancer treatment: A double-edged sword
Y Gao, Q Shang, W Li, W Guo, A Stojadinovic… - Journal of …, 2020 - ncbi.nlm.nih.gov
Various antibiotics have been used in the treatment of cancers, via their anti-proliferative,
pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However …
pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However …
Antibiotic discovery: where have we come from, where do we go?
B Ribeiro da Cunha, LP Fonseca, CRC Calado - Antibiotics, 2019 - mdpi.com
Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …
Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis
SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - Am Soc Microbiol
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
An omics perspective on drug target discovery platforms
J Paananen, V Fortino - Briefings in bioinformatics, 2020 - academic.oup.com
The drug discovery process starts with identification of a disease-modifying target. This
critical step traditionally begins with manual investigation of scientific literature and …
critical step traditionally begins with manual investigation of scientific literature and …
The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens
J Shin, VS Prabhakaran, K Kim - Microbial pathogenesis, 2018 - Elsevier
Multidrug-resistant (MDR) pathogens are currently causing serious problems globally in the
medical setting. Improper and extensive usage of antibiotics results in a selective pressure …
medical setting. Improper and extensive usage of antibiotics results in a selective pressure …
A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance
V Thakur, A Uniyal, V Tiwari - European Journal of Pharmacology, 2021 - Elsevier
The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic
application over time. In recent decades, antibiotic resistance has become one of the most …
application over time. In recent decades, antibiotic resistance has become one of the most …
Diversity, ecology, and prevalence of antimicrobials in nature
Microorganisms possess a variety of survival mechanisms, including the production of
antimicrobials that function to kill and/or inhibit the growth of competing microorganisms …
antimicrobials that function to kill and/or inhibit the growth of competing microorganisms …
Omics of antimicrobials and antimicrobial resistance
VM Chernov, OA Chernova… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: The development of new antimicrobials has become an urgent priority because
of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas …
of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas …