Abstract The purine analogue, 8-chloro-adenosine (8-Cl-Ado), induces apoptosis in a
number of multiple myeloma (MM) cell lines. This ribonucleoside analogue accumulates as …

Abstract Myeloid cell leukemia-1 (MCL-1) acts as a key survival factor for chronic
lymphocytic leukemia (CLL) cells. In addition, dissipation of cellular bioenergy may impose a …

Chloro-adenosine (8-CI-Ado) is a potent chemotherapeutic agent whose cytotoxicity in a
variety of tumor cell lines has been widely investigated. However, the molecular …

8-Chloro-cAMP and 8-chloro-adenosine (8-Cl-Ado) are known to inhibit proliferation of
cancer cells by converting 8-Cl-Ado into an ATP analog, 8-chloro-ATP (8-Cl-ATP). Because …

A key feature of actin is its ability to bind and hydrolyze ATP. 8-Chloro-adenosine (8-Cl-Ado),
which can be phosphorylated to the moiety of 8-Cl-ATP in living cells, inhibits tumor cell …

The nucleotide substrate specificity of yeast poly (A) polymerase (yPAP) toward various C-2-
and C-8-modified ATP analogs was examined. 32 P-Radiolabeled RNA oligonucleotide …

8-Alkoxyadenosines have the potential to exist in anti or syn conformations around the
glycosidic bond when paired opposite to U or G in the complementary strands, thereby …

We report the inhibition of mammalian polyadenylation by the triphosphate derivatives of
adenosine analogues, 8-chloroadenosine (8-Cl-Ado) and 8-aminoadenosine (8-amino …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor
necrosis factor (TNF) super-family, induces apoptosis in various cancer cells with little or no …

Modified nucleobase analogues can serve as powerful tools for changing physicochemical
and biological properties of DNA or RNA. Guanosine derivatives containing bulky …