Chondroitin sulfate “wobble motifs” modulate maintenance and differentiation of neural stem cells and their progeny

A Purushothaman, K Sugahara, A Faissner - Journal of Biological …, 2012 - ASBMB
Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the
central nervous system, have the potential to interact with a wide range of growth factors and …

Future perspectives of cell therapy for neonatal hypoxic–ischemic encephalopathy

M Nabetani, H Shintaku, T Hamazaki - Pediatric Research, 2018 - nature.com
Neonatal ischemic brain injury causes permanent motor-deficit cerebral palsy. Hypoxic–
ischemic encephalopathy (HIE) is a very serious condition that can result in death and …

Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal …

T Suzuki, Y Sato, Y Kushida, M Tsuji… - Journal of Cerebral …, 2021 - journals.sagepub.com
Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction
and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) …

Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice

JH Yi, Y Katagiri, B Susarla, D Figge… - Journal of …, 2012 - Wiley Online Library
Chondroitin sulfate proteoglycans (CSPGs) play a pivotal role in many neuronal growth
mechanisms including axon guidance and the modulation of repair processes following …

Intravenous administration of bone marrow-derived mesenchymal stem cell, but not adipose tissue-derived stem cell, ameliorated the neonatal hypoxic-ischemic brain …

Y Sugiyama, Y Sato, Y Kitase, T Suzuki… - Frontiers in …, 2018 - frontiersin.org
Perinatal hypoxic-ischemic (HI) brain injury occurs in 1 in 1,000 live births and remains the
main cause of neurological disability and death in term infants. Cytotherapy has recently …

ADSC therapy in neurodegenerative disorders

TM Chan, JYR Chen, LI Ho, HP Lin… - Cell …, 2014 - journals.sagepub.com
Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily
life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's …

Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats

T Hattori, Y Sato, T Kondo, Y Ichinohashi… - Developmental …, 2015 - karger.com
This study aimed to investigate whether the administration of mononuclear cells derived
from human umbilical cord blood cells (UCBCs) could ameliorate hypoxic-ischemic brain …

Advanced progress in the role of adipose-derived mesenchymal stromal/stem cells in the application of central nervous system disorders

H Wu, Y Fan, M Zhang - Pharmaceutics, 2023 - mdpi.com
Currently, adipose-derived mesenchymal stromal/stem cells (ADMSCs) are recognized as a
highly promising material for stem cell therapy due to their accessibility and safety. Given the …

Rat umbilical cord blood cells attenuate hypoxic–ischemic brain injury in neonatal rats

K Nakanishi, Y Sato, Y Mizutani, M Ito, A Hirakawa… - Scientific Reports, 2017 - nature.com
Increasing evidence has suggested that human umbilical cord blood cells (hUCBC) have a
favorable effect on hypoxic–ischemic (HI) brain injury. However, the efficacy of using …

Cell-based treatment for perinatal hypoxic-ischemic encephalopathy

YJ Park, CV Borlongan, M Dezawa - Brain Circulation, 2021 - journals.lww.com
Hypoxic-ischemic encephalopathy (HIE) is a major cause of acute neonatal brain injury and
can lead to disabling long-term neurological complications. Treatment for HIE is limited to …