Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma

EJ Sun, M Wankell, P Palamuthusingam, C McFarlane… - Biomedicines, 2021 - mdpi.com
Despite advances in the treatment of cancers through surgical procedures and new
pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as …

[HTML][HTML] Tumor-associated macrophages in hepatocellular carcinoma: friend or foe?

D Zhou, J Luan, C Huang, J Li - Gut and Liver, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it
has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at …

[HTML][HTML] PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

G Sharma, R Ojha, E Noguera-Ortega, VW Rebecca… - JCI insight, 2020 - ncbi.nlm.nih.gov
New strategies are needed to enhance the efficacy of anti–programmed cell death protein
antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein …

Preclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation

W Chen, Z Ma, L Yu, X Mao, N Ma, X Guo… - … & Molecular Medicine, 2022 - nature.com
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma
(HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART …

Autophagy, an accomplice or antagonist of drug resistance in HCC?

Y Wu, J Zhang, Q Li - Cell Death & Disease, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal malignancy characterized by poor
prognosis and a low 5-year survival rate. Drug treatment is proving to be effective in anti …

[HTML][HTML] Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications

L Zou, M Liao, Y Zhen, S Zhu, X Chen, J Zhang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

The role of autophagy in liver cancer: crosstalk in signaling pathways and potential therapeutic targets

J Cui, HM Shen, LHK Lim - Pharmaceuticals, 2020 - mdpi.com
Autophagy is an evolutionarily conserved lysosomal-dependent pathway for degrading
cytoplasmic proteins, macromolecules, and organelles. Autophagy-related genes (Atgs) are …

Small molecule inhibitors for Unc-51-like autophagy-activating kinase targeting autophagy in cancer

U Karmacharya, JW Jung - International journal of molecular sciences, 2023 - mdpi.com
Autophagy is a cellular process that removes damaged components of cells and recycles
them as biochemical building blocks. Autophagy can also be induced to protect cells in …

[HTML][HTML] Radioembolization for the treatment of hepatocellular carcinoma

HC Kim - Clinical and molecular hepatology, 2017 - ncbi.nlm.nih.gov
Transarterial radioembolization (TARE) with yttrium 90 (90 Y), an intra-arterial procedure
performed by interventional radiologists, has begun being utilized in managing …

Multicolored and high optical contrast flexible electrochromic devices based on viologen derivatives

W Ye, X Guo, X Zhang, P Liu - Synthetic Metals, 2022 - Elsevier
Abstract Three viologen derivatives: 1, 1′-(4-indolyphenyl)-4, 4′-bipyridine
dihexafluorophosphate (2IV), 1, 1′-(4-phenothiazinylphenyl)-4, 4′-bipyridine …