The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

[HTML][HTML] Molecular mechanisms underlying neuroinflammation elicited by occupational injuries and toxicants

D Pathak, K Sriram - International Journal of Molecular Sciences, 2023 - mdpi.com
Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

[HTML][HTML] Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

[HTML][HTML] Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

H Wang, XM Zhou, LY Wu, GJ Liu, WD Xu… - Journal of …, 2020 - Springer
Abstract Background Aucubin (Au), an iridoid glycoside from natural plants, has
antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain …

[HTML][HTML] Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

X Xu, D Yin, H Ren, W Gao, F Li, D Sun, Y Wu… - Neurobiology of …, 2018 - Elsevier
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …

[HTML][HTML] Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

JR Wu, Y Hernandez, KF Miyasaki, EJ Kwon - Advanced drug delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury

X Zhao, W Zeng, H Xu, Z Sun, Y Hu, B Peng… - Science translational …, 2023 - science.org
Tau pathogenesis is a hallmark of many neurodegenerative diseases, including Alzheimer's
disease (AD). Although the events leading to initial tau misfolding and subsequent tau …

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway

J Wang, C Jiang, K Zhang, X Lan, X Chen… - Free radical biology and …, 2019 - Elsevier
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin,
a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant …

Carbogenic nanozyme with ultrahigh reactive nitrogen species selectivity for traumatic brain injury

X Mu, H He, J Wang, W Long, Q Li, H Liu, Y Gao… - Nano …, 2019 - ACS Publications
Reactive oxygen and nitrogen species (RONS), especially reactive nitrogen species (RNS)
are intermediate products during incidence of nervous system diseases, showing …