[HTML][HTML] Immunotherapy for Parkinson's disease

AD Schwab, MJ Thurston, J Machhi, KE Olson… - Neurobiology of …, 2020 - Elsevier
With the increasing prevalence of Parkinson's disease (PD), there is an immediate need to
interdict disease signs and symptoms. In recent years this need was met through therapeutic …

The role of mtDAMPs in the trauma-induced systemic inflammatory response syndrome

J Ye, X Hu, Z Wang, R Li, L Gan, M Zhang… - Frontiers in …, 2023 - frontiersin.org
Systemic inflammatory response syndrome (SIRS) is a non-specific exaggerated defense
response caused by infectious or non-infectious stressors such as trauma, burn, surgery …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

MiR-17–92 cluster-enriched exosomes derived from human bone marrow mesenchymal stromal cells improve tissue and functional recovery in rats after traumatic …

Y Zhang, Y Zhang, M Chopp, H Pang… - Journal of …, 2021 - liebertpub.com
Exosomes play an important role in intercellular communication by delivering
microribonucleic acids (miRNAs) to recipient cells. Previous studies have demonstrated that …

Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice

J Wang, Y Lu, C Carr, KM Dhandapani… - Frontiers in …, 2023 - frontiersin.org
Introduction Chronic neuroinflammation can exist for months to years following traumatic
brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods …

Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury

H Jia, X Liu, Y Cao, H Niu, L Zhang, RJ Li, F Li, D Sun… - Brain Research, 2023 - Elsevier
Traumatic brain injury (TBI) is an important reason of neurological damage and has high
morbidity and mortality rates. The secondary damage caused by TBI leads to a poor clinical …

L-serine, an endogenous amino acid, is a potential neuroprotective agent for neurological disease and injury

L Ye, Y Sun, Z Jiang, G Wang - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
Central nervous system (CNS) lesions are major causes of human death and disability
worldwide, and they cause different extents of motor and sensory dysfunction in patients …

Core-cross-linked nanoparticles reduce neuroinflammation and improve outcome in a mouse model of traumatic brain injury

D Yoo, AW Magsam, AM Kelly, PS Stayton, FM Kievit… - ACS …, 2017 - ACS Publications
Traumatic brain injury (TBI) is the leading cause of death and disability in children and
young adults, yet there are currently no treatments available that prevent the secondary …

IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function

R Schneider, P Leven, S Mallesh, M Breßer… - Communications …, 2022 - nature.com
Abstract Muscularis Externa Macrophages (ME-Macs) and enteric glial cells (EGCs) are
closely associated cell types in the bowel wall, and important interactions are thought to …

[HTML][HTML] Traumatic brain injury in women across lifespan

MO Blaya, AP Raval, HM Bramlett - Neurobiology of disease, 2022 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death and disability and a global public
health challenge. Every year more than 50 million people suffer a TBI, and it is estimated …