Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

Gap junctions (GJs) are the only known cellular structures that allow a direct transfer of
signaling molecules from cell-to-cell by forming hydrophilic channels that bridge the …

Gap junctions consist of arrays of intercellular channels between adjacent cells that permit
the exchange of ions and small molecules. Here we report the crystal structure of the gap …

Hearing impairment (HI) affects 1 in 650 newborns, which makes it the most common
congenital sensory impairment. Despite extraordinary genetic heterogeneity, mutations in …

Gap junctions were initially described morphologically, and identified as semi-crystalline
arrays of channels linking two cells. This suggested that they may represent an amenable …

Pannexins are homologous to innexins, the invertebrate gap junction family. However,
mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric …

Gap junctions consist of arrays of intercellular channels composed of integral membrane
proteins called connexin in vertebrates. Gap junction channels regulate the passage of ions …

Gap junctions are comprised of connexins that form cell-to-cell channels which couple
neighboring cells to accommodate the exchange of information. The need for …

Connexin molecules form intercellular membrane channels facilitating electronic coupling
and the passage of small molecules between adjoining cells. Connexin26 (Cx26) is the …

Gap-junction channels connect the cytoplasm of adjacent cells, allowing the diffusion of ions
and small metabolites. They are formed at the appositional plasma membranes by a family …