Sequential modifications of the RNA polymerase II (Pol II) C-terminal domain (CTD)
coordinate the stage-specific association and release of cellular machines during …

The predominant organizational theme by which the transcription machinery and chromatin
regulators are positioned within promoter regions or throughout genes in a genome is …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …

We measure transcriptional noise in yeast by analyzing chromatin structure and transcription
of an 18-kb region of DNA whose sequence was randomly generated. Nucleosomes fully …

The RNA exosome is a highly conserved ribonuclease endowed with 3′–5′ exonuclease
and endonuclease activities. The multisubunit complex resides in both the nucleus and the …

Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …

The exosome is a multi-subunit 3′-5′ exonucleolytic complex that is conserved in
structure and function in all eukaryotes studied to date. The complex is present in both the …

Recruitment of appropriate RNA processing factors to the site of transcription is controlled by
post-translational modifications of the C-terminal domain (CTD) of RNA polymerase II …

The advent of high‐throughput sequencing technologies has revealed that pervasive
transcription generates RNAs from nearly all regions of eukaryotic genomes. Normally …