Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …

The tight junction proteins claudins are abnormally regulated in several human cancers. In
particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias …

One of the most strikingrags to riches' stories in the protein world is that of 14-3-3, originally
identified in 1967 as merely an abundant brain protein. The first clues that 14-3-3 would play …

The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological
functions, and their ratio varies widely in breast cancers. To determine whether the two PR …

Claudins are transmembrane proteins that seal tight junctions, and are critical for
maintaining cell-to-cell adhesion in epithelial cell sheets. However, their role in cancer …

Difficulties in the detection, diagnosis, and treatment of ovarian cancer result in an overall
low survival rate of women with this disease. A better understanding of the pathways …

Purpose: Claudin proteins represent a large family of integral membrane proteins crucial for
tight junction (TJ) formation and function. Claudins have been shown to be up-regulated in …

Expression of 14-3-3 σ (σ) is induced in response to DNA damage, and causes cells to
arrest in G2. By SAGE (serial analysis of gene expression) analysis, we identified σ as a …

Metastases are the major cause of cancer-related deaths in patients with solid epithelial
malignancies, such as breast, colorectal, and prostate carcinomas. Hematogenous …