Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …

Biofabrication technologies, including stereolithography and extrusion‐based printing, are
revolutionizing the creation of complex engineered tissues. The current paradigm in …

Regenerative medicine is a new and promising mode of therapy for patients who have
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …

Wound healing is an important function of skin; however, after significant skin injury (burns)
or in certain dermatological pathologies (chronic wounds), this important process can be …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though
they are generally non-toxic, in some cases, they may not provide suitable support for cell …

An appropriate immune microenvironment, governed by macrophages, is essential for rapid
tissue regeneration after biomaterial implantation. The macrophage phenotypes, M1 …

The mammalian brain contains few niches for neural stem cells (NSCs) capable of
generating new neurons, whereas other regions are primarily gliogenic. Here we leverage …

Extracellular matrix (ECM) provides both structural support and dynamic microenvironment
for cells regulating their behavior and fate. As a critical component of stem cell niche ECM …