The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

Bacilli secrete numerous proteins into the environment. Many of the secretory proteins, their
export signals, and their processing steps during secretion have been characterized in …

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state,
applicability, and limitations of modeling the dynamics of cellular networks. We integrate …

To address the role of phospholipids in the topological organization of polytopic membrane
proteins, the function and assembly of lactose permease (LacY) was studied in mutants of …

YidC of Echerichia coli, a member of the conserved Alb3/Oxa1/YidC family, is postulated to
be important for biogenesis of membrane proteins. Here, we use as a model the lactose …

Tn5 insertion mutations of Escherichia coli were isolated that impaired the formation of
correctly folded alkaline phosphatase (PhoA) in the periplasm. The PhoA polypeptide …

Escherichia coli FtsH (HflB), a membrane‐bound ATPase is required for proteolytic
degradation of uncomplexed forms of the protein translocase SecY subunit. We have now …

Bacteria can be subdivided on the basis of the structure of the cell envelope into Gram-
negative and Gram-positive. The cell envelope of Gram-negative bacteria is composed of a …

Gram-negative bacteria assemble many proteins into the inner and outer membranes and
export a large number of proteins to the periplasm or to the extracellular medium. During the …

The insertion and assembly of proteins into the inner membrane of bacteria are crucial for
many cellular processes, including cellular respiration, signal transduction, and ion and pH …