Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

Abstract Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the
combination of genetic and environmental factors, and obesity, lifestyle, and aging are the …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …

Background Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but
there is no specific therapy for diabetic heart disease. Sodium glucose transporter 2 …

Cardiac hypertrophy is an important characteristic in the development of hypertensive heart
disease. Mitochondrial dysfunction plays an important role in the pathology of cardiac …

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach,
given that mitochondrial defects are thought to contribute to many prevalent diseases and …

In recent years, epigenetic modifications have been widely researched. As humans age,
environmental and genetic factors may drive inflammation and immune responses by …