The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Pluripotency reprogramming and transdifferentiation induced by transcription factors can
generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the …

The pygmy killer whale (Feresa attenuata)(PKW) is a tropical and subtropical marine
mammal commonly found in the Atlantic, Indian and Pacific oceans. Since the PKWs live in …

Parkinson's disease is mainly caused by specific degeneration of dopaminergic neurons
(DA neurons) in the substantia nigra of the middle brain. Over the past two decades …

The presence of polybrominated diphenyl ethers (PBDEs) in the aquatic environment is an
issue of major concern which may be a cause of increasing prevalence and severity of …

Chemical transdifferentiation is a technique that utilizes small molecules to directly convert
one cell type into another without passing through an intermediate stem cell state. This …

Transplantation of motor neurons can provide long-term functional benefits in animal models
of neurodegenerative motor neuron diseases such as amyotrophic lateral sclerosis and …

Cell replacement is a promising approach for neurodegenerative disease treatment.
Somatic cells such as fibroblasts can be induced to differentiate into neurons by specific …

We aimed to verify whether the intravitreal injection of small molecule compounds alone can
create photoreceptor cells in mouse models of retinal degeneration. Primary cultured mouse …

Transplantation of reprogrammed cells from accessible sources and in vivo reprogramming
are potential therapies for regenerative medicine. During the last decade, genetic …