Rather than primary solid tumors, metastasis is one of the hallmarks of most cancer deaths.
Metastasis is a multistage event in which cancer cells escape from the primary tumor survive …

The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–
organ interaction is a key mechanism and a concept that enables an understanding of all …

Colorectal cancer (CRC) is a common malignant tumor characterized by unchecked division
and survival of abnormal cells in the colon or rectum with high morbidity and mortality …

Inflammation is closely related with the progression of cancer and is an indispensable
component that orchestrates the tumor microenvironment. Studies suggest that different …

Tumour-associated macrophages (TAMs) have been found to be of great importance in
tumorigenesis and in promoting malignant progression, including tumour angiogenesis and …

Abstract Changes in serum inflammatory factors occur throughout the onset and multiple
myeloma (MM) progression, the feedback loops make it harder to distinguish between …

Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …

Bone marrow (BM) microenvironment contributes to the regulation of normal hematopoiesis
through a finely tuned balance of self-renewal and differentiation processes, cell–cell …

Abstract Interleukin 6 (IL‑6), a cytokine produced by various cells of the human body
(macrophages, lymphocytes, astrocytes, ischemic myocytes, endothelial cells) has both pro …

IL-6 pathway is abnormally hyperactivated in several cancers triggering tumor cell growth
and immune system inhibition. Along with genomic mutation, the IL6 pathway gene …