My PhD dissertation aims (1) at reconstructing the structure of the context of discovery of
'data-driven'(big data, data intensive) biology and (2) at comparing it to traditional molecular …

The development of targeted therapy has promised a new era in cancer therapy by
improving response rates and fewer side effects of the therapeutics on normal cells. As the …

Obgleich bekannt ist, dass die Ausprägung zahlreicher neuropsychiatrischer Erkrankungen
genetisch bedingt ist, sind die grundlegenden Mechanismen dieses Zusammenhangs noch …

1.1. Schematic representation of the stress hormone system........... 4 1.2. Genetic association
mapping of genome-wide gene expression data..... 19 1.3. Effect of cis-acting variants on …

Zusammenfassung Der Transkriptionsfaktor Sox2 spielt eine wichtige Rolle in der
Embryonalentwicklung des zentralen Nervensystems und in verschiedenen Tumorarten des …

Early interpersonal traumata (related to such experiences as childhood physical or sexual
abuse) are disturbingly common in individuals with bulimia-spectrum disorders (BSDs) …

Predictive, preventative and personalized medicine is increasingly becoming a reality with
recent advances to whole genome sequencing. Genome wide association studies wield …

Περίληψη Η προεκλαμψία είναι μία πολυσυστηματική διαταραχή που επιπλέκει το 2-8% των
κυήσεων παγκοσμίως ενώ συνιστά παράλληλα σημαντική αιτία μητρικής και νεογνικής …

Major mental illness is now recognised as one of the leading causes of adult morbidity. Of
the adult onset psychiatric disorders, the functional psychoses (schizophrenia, bipolar …

Multiple Sclerosis (MS) is a major, inflammatory and demyelinating, chronic disorder of the
Central Nervous System (CNS), affecting most commonly young adults. It is generally …