Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs)
are being phased out of commercial use, leading to the increased use of alternative …

A long-term goal of numerous research projects is to identify biomarkers for in vitro systems
predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated
diphenyl ethers are banned from the market and replaced by alternative FRs, like …

Assessment of the network of toxicity pathways by Omics technologies and bioinformatic
data processing paves the road toward a new toxicology for the twenty-first century …

Millions of children are born each year with a birth defect. Many of these defects are caused
by environmental factors, although the underlying etiology is often unknown. In vivo …

Dear editor, It is well known that huge research networks have been initiated by the EU to
establish in vitro test systems for toxicity testing (Liebsch et al., 2011; Bolt, 2013; Krug et al …

Test systems to identify developmental toxicants are urgently needed. A combination of
human stem cell technology and transcriptome analysis was to provide a proof of concept …

Information on design principles governing transcriptome changes upon transition from safe
to hazardous drug concentrations or from tolerated to cytotoxic drug levels are important for …

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …