The superordinate principles governing the transcriptome response of differentiating cells
exposed to drugs are still unclear. Often, it is assumed that toxicogenomics data reflect the …

Stem cell-based in vitro test systems can recapitulate specific phases of human
development. In the UKK test system, human pluripotent stem cells (hPSCs) randomly …

There is need in the pharmaceutical and chemical industries for high-throughput human cell-
based assays for identifying hazardous chemicals, thereby reducing the overall reliance on …

Background The exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely
unknown. We intended to authenticate critical genes linked to T2DM progression by tandem …

Primary human hepatocytes (PHHs) remain the gold standard for in vitro testing in the field
of pharmacology and toxicology. One crucial parameter influencing the results of in vitro …

Developmental toxicity in vitro assays have hitherto been established as stand-alone
systems, based on a limited number of toxicants. Within the embryonic stem cell-based …

To investigate long-term trends of animal use, the EU animal use statistics from the 15
countries that have been in the EU since 1995 plus respective data from Switzerland were …

Thousands of compounds in the environment have not been characterized for
developmental neurotoxicity (DNT) hazard. To address this issue, methods to screen …

Less than 1% of environmental chemicals have been evaluated for developmental
neurotoxicity (DNT). Current guideline DNT studies are resource intensive and not …

Early assessment of the toxicity potential of new molecules in pharmaceutical industry is a
multi‐dimensional task involving predictive systems and screening approaches to aid in the …