Availability of homogeneous astrocyte populations would facilitate research concerning cell
plasticity (metabolic and transcriptional adaptations; innate immune responses) and cell …

For some complex toxicological endpoints, chemical safety assessment has conventionally
relied on animal testing. Apart from the ethical issues, also scientific considerations have …

Flame retardants are detected in the environment worldwide, and thus pose great risks to
human health. The potential effects of these chemicals on the development of the central …

Valproic acid (VPA) is a very potent anti-cancer and neuro-protective drug probably by its
HDAC inhibiting properties, which may cause steatosis in the liver. The present study …

The potential for adverse neurotoxic reactions in response to therapeutics and
environmental hazards continues to prompt development of novel cell-based assays to …

Migration of neural crest cells (NCCs) is one of the pivotal processes of human fetal
development. Malformations arise, if NCC migration and differentiation are impaired …

The nervous system has a highly complex organization, including many cell types with
multiple functions, with an intricate anatomy and unique structural and functional …

Efficient protocols to differentiate human pluripotent stem cells to various tissues in
combination with-omics technologies opened up new horizons for in vitro toxicity testing of …

The in vitro test battery of the European research consortium ESNATS ('novel stem cell-
based test systems') has been used to screen for potential human developmental toxicants …

Analysis of transcriptome changes has become an established method to characterize the
reaction of cells to toxicants. Such experiments are mostly performed at compound …