Challenges and opportunities for engineered Escherichia coli as a pivotal chassis toward versatile tyrosine-derived chemicals production

SSW Effendi, IS Ng - Biotechnology Advances, 2023 - Elsevier
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of high-volume fuels …

Nutrient stress is a target for new antibiotics

LA Carfrae, ED Brown - Trends in microbiology, 2023 - cell.com
Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …

Local flux coordination and global gene expression regulation in metabolic modeling

G Li, L Liu, W Du, H Cao - Nature Communications, 2023 - nature.com
Genome-scale metabolic networks (GSMs) are fundamental systems biology
representations of a cell's entire set of stoichiometrically balanced reactions. However, such …

Metabolic reprogramming and biosensor-assisted mutagenesis screening for high-level production of L-arginine in Escherichia coli

S Jiang, R Wang, D Wang, C Zhao, Q Ma, H Wu… - Metabolic …, 2023 - Elsevier
L-arginine is a value-added amino acid with promising applications in the pharmaceutical
and nutraceutical industries. Further unleashing the potential of microbial cell factories to …

Ultrasound-assisted activation of PAW residual radicals in the concurrent elimination of ARB and ARGs: process efficiency, mechanism and implication

Z Hu, W Xu, Y Sun, H Xu, J Xu, L Huang, W Yao… - Chemical Engineering …, 2024 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) and antibiotic resistance gene (mecA)
are considered emerging contaminants that have been extensively identified in aqueous …

Microbial production of L-methionine and its precursors using systems metabolic engineering

M Cai, Z Liu, Z Zhao, H Wu, M Xu, Z Rao - Biotechnology Advances, 2023 - Elsevier
L-methionine is an essential amino acid with versatile applications in food, feed, cosmetics
and pharmaceuticals. At present, the production of L-methionine mainly relies on chemical …

Recent advances in the metabolic engineering and physiological opportunities for microbial synthesis of L-aspartic acid family amino acids: A review

Y Wang, Y Bai, Q Zeng, Z Jiang, Y Liu, X Wang… - International Journal of …, 2023 - Elsevier
L-aspartic acid, L-threonine, L-isoleucine, l-lysine, and L-methionine constitute the l-
aspartate amino acids (AFAAs). Except for L-aspartic acid, these are essential amino acids …

Photoacidolysis-mediated iridium (III) complex for photoactive antibacterial therapy

Y Li, S Luo, H Wang, Y Lai, D Li, Q Zhang… - Journal of Medicinal …, 2023 - ACS Publications
Photoactive antibacterial therapy is one of the novel therapeutic methods that has great
application potential and prospects for curbing bacterial infections. In this work, a …

Microbial production of sulfur-containing amino acids using metabolically engineered Escherichia coli

L Wang, Y Guo, Y Shen, K Yang, X Cai, B Zhang… - Biotechnology …, 2024 - Elsevier
L-Cysteine and L-methionine, as the only two sulfur-containing amino acids among the
canonical 20 amino acids, possess distinct characteristics and find wide-ranging industrial …

Complete characterization of robust perfect adaptation in biochemical reaction networks

Y Hirono, A Gupta, M Khammash - arXiv preprint arXiv:2307.07444, 2023 - arxiv.org
Perfect adaptation is a phenomenon whereby the output variables of a system can maintain
certain values despite external disturbances. Robust perfect adaptation (RPA) refers to an …