Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

There is a long-standing paradox that NMDA (N-methyl-d-aspartate) receptors (NMDARs)
can both promote neuronal health and kill neurons. Recent studies show that NMDAR …

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors
have opposite effects on CREB (cAMP response element binding protein) function, gene …

Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists (competitive receptor
antagonists, ion channel blockers, and glycine antagonists)—such as selfotel, aptiganel …

The penumbra is an area of brain tissue that is damaged but not yet dead after focal
ischemia. The existence of a penumbra implies that therapeutic salvage is theoretically …

Ca 2+ entry through the NMDA subtype of glutamate receptors has the power to determine
whether neurons survive or die. Too much NMDA receptor activity is harmful to neurons–but …

Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted …

Only very little is know about the neurovascular niche after cardioembolic stroke. Three
processes implicated in neurorepair: angiogenesis, neurogenesis and synaptic plasticity …

NMDA (N-methyl-d-aspartate) receptors are a subtype of ionotropic glutamate receptor with
an important role in the physiology and pathophysiology of central neurons. Inappropriate …

In vitro models of traumatic brain injury (TBI) are helping elucidate the pathobiological
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …