Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Renal proximal tubular cells are the most energy-demanding cells in the body. The ATP that
they use is mostly produced in their mitochondrial and peroxisomal compartments, by the …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Work during the past several years has produced new insights into many aspects of the cell
biology of ischemic injury to the tubulointerstitium. The major processes are conveniently …

ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …

Hypoxia stimulates proximal tubular cell matrix production via a TGF-β 1-independent
mechanism. Tubulointerstitial fibrosis is characterized by tubular basement membrane …

The promotion of cell survival and regeneration in acute renal failure (ARF) is important for
restitution of renal function. This study analyzes the temporal and spatial relationship …

We have analyzed glomerular sieving data from humans, rats in vivo, and from isolated
perfused rat kidneys (IPK) and present a unifying hypothesis that seems to resolve most of …

Loop diuretics reduce hypoxic damage to proximal tubules of the isolated perfused rat
kidney. The straight portion (S3) of the proximal tubule lies in close proximity to the thick …

The fractional clearances (θ) for FITC-Ficoll and albumin were estimated in isolated
perfused rat kidneys in which the tubular activity was inhibited by low temperature (8° C) …