[HTML][HTML] Recurrent implantation failure: reality or a statistical mirage?: Consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure
P Pirtea, MI Cedars, K Devine, B Ata, J Franasiak… - Fertility and sterility, 2023 - Elsevier
Importance To date, recurrent implantation failure (RIF) has no clear definition and no clearly
identified impaired function. Hence, the term RIF is currently used somewhat haphazardly …
identified impaired function. Hence, the term RIF is currently used somewhat haphazardly …
[HTML][HTML] Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
[HTML][HTML] NADase CD38 is a key determinant of ovarian aging
Q Yang, W Chen, L Cong, M Wang, H Li, H Wang… - Nature Aging, 2024 - nature.com
The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …
[HTML][HTML] Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss
Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …
prevalence of these abnormalities and the allocation of (ab) normal cells in embryonic and …
[HTML][HTML] Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly
FL Zhang, WD Li, KX Zhu, X Zhou, L Li, TL Lee… - Cell Death …, 2023 - nature.com
Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of
how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel …
how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel …
Deletion of enzymes for de novo NAD+ biosynthesis accelerated ovarian aging
Q Yang, H Li, H Wang, W Chen, X Zeng, X Luo… - Aging …, 2023 - Wiley Online Library
Recent advances highlight the pivotal role of nicotinamide adenine dinucleotide (NAD+) in
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …
ovarian aging. However, the roles of de novo NAD+ biosynthesis on ovarian aging are still …
Spindle assembly checkpoint insensitivity allows meiosis‐II despite chromosomal defects in aged eggs
Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally
compromised aneuploid embryos and become more common with advancing maternal age …
compromised aneuploid embryos and become more common with advancing maternal age …
[HTML][HTML] Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
SS Dipali, CD King, JP Rose, JE Burdette… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased
collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex …
collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex …
[HTML][HTML] Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
B Guo, S Zhang, S Wang, H Zhang, J Fang… - Reproductive Biology …, 2023 - Springer
Background With advanced maternal age, abnormalities during oocyte meiosis increase
significantly. Aneuploidy is an important reason for the reduction in the quality of aged …
significantly. Aneuploidy is an important reason for the reduction in the quality of aged …
[HTML][HTML] Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq
Y Wang, Y Chen, J Gao, H Xie, Y Guo, J Yang, J Liu… - Cell Discovery, 2024 - nature.com
Single-cell whole-genome sequencing methods have undergone great improvements over
the past decade. However, allele dropout, which means the inability to detect both alleles …
the past decade. However, allele dropout, which means the inability to detect both alleles …