The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

Colonization by the microbiota causes a marked stimulation of B cells and induction of
immunoglobulin, but mammals colonized with many taxa have highly complex and …

The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To
identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were …

The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …

An optimal immune response should differentiate between harmful and innocuous antigens.
Primitive systems of innate immunity, such as the complement system, may play a role in this …

The complement (C) inflammatory cascade is part of the phylogenetically ancient innate
immune response and is crucial to our natural ability to ward off infection. It has three critical …

There are many links between the complement system and the autoimmune disease
systemic lupus erythematosus (SLE). Soon after the identification of antinuclear antibodies …

The mannan-binding lectin (MBL) pathway of complement activation is part of the innate
immune defense. The binding of MBL to microbial carbohydrates activates the MBL …