Molecular imaging with PET

SM Ametamey, M Honer, PA Schubiger - Chemical reviews, 2008 - ACS Publications
Recent advances in noninvasive imaging modalities have opened endless opportunities for
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …

Chemistry with [18F]Fluoride Ion

L Cai, S Lu, VW Pike - European Journal of Organic Chemistry, 2008 - Wiley Online Library
The success of molecular imaging with positron‐emission tomography (PET) depends on
the availability of selective molecular probes labeled with positron‐emitters, such asfluorine …

Metal‐free catalyst for the chemoselective methylation of amines using carbon dioxide as a carbon source

S Das, FD Bobbink, G Laurenczy… - Angewandte Chemie …, 2014 - Wiley Online Library
N‐methylation of amines is an important step in the synthesis of many pharmaceuticals and
has been widely applied in the preparation of other key intermediates and chemicals …

Improved 18F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex

WJ McBride, CA D'Souza, RM Sharkey… - Bioconjugate …, 2010 - ACS Publications
We reported previously the feasibility to radiolabel peptides with fluorine-18 (18F) using a
rapid one-pot method that first mixes 18F− with Al3+ and then binds the (Al18F) 2+ complex …

Fluorine-18 radiopharmaceuticals beyond [18F] FDG for use in oncology and neurosciences

HH Coenen, PH Elsinga, R Iwata, MR Kilbourn… - Nuclear medicine and …, 2010 - Elsevier
Positron emission tomography (PET) is a rapidly expanding clinical modality worldwide
thanks to the availability of compact medical cyclotrons and automated chemistry for the …

Protein and peptides in pictures: imaging with MALDI mass spectrometry

RJA Goodwin, SR Pennington, AR Pitt - Proteomics, 2008 - Wiley Online Library
Imaging using MS has the potential to deliver highly parallel, multiplexed data on the
specific localization of molecular ions in tissue samples directly, and to measure and map …

Enhanced Aqueous Suzuki–Miyaura Coupling Allows Site-Specific Polypeptide 18F-Labeling

Z Gao, V Gouverneur, BG Davis - Journal of the American …, 2013 - ACS Publications
The excesses of reagents used in protein chemistry are often incompatible with the reduced
or even inverse stoichiometries used for efficient radiolabeling. Analysis and screening of …

Recent trends in bioorthogonal click-radiolabeling reactions using fluorine-18

M Pretze, D Pietzsch, C Mamat - Molecules, 2013 - mdpi.com
The increasing application of positron emission tomography (PET) in nuclear medicine has
stimulated the extensive development of a multitude of novel and versatile bioorthogonal …

Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine …

RJA Goodwin, CL Mackay, A Nilsson… - Analytical …, 2011 - ACS Publications
The distributions of positron emission tomography (PET) ligands in rat brain tissue sections
were analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging …

18F‐Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts

L Mu, CR Fischer, JP Holland, J Becaud, PA Schubiger… - 2012 - Wiley Online Library
A new method for the 18F‐radiolabeling of aromatic compounds based on the aromatic
nucleophilic substitution (SNAr) reaction using triarylsulfonium salts has been developed …