MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse
biological processes, particularly breast cancer (BC) development. Within the imprinting …

Bergapten is a natural furocoumarin, also known as 5‐methoxypsoralen, and its medicinal
value has been paid more and more attention. By sorting out the pharmacological literature …

The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …

Simple Summary Although conventional anti-cancer drugs have been the footstone in the
fight against cancer, yet they are far from optimal due to issues related with indiscriminate …

Background Breast cancer is the leading cause of cancer death in women. Chemotherapy to
inhibit the proliferation of cancer cells is considered to be the most important therapeutic …

Background: Silibinin (SB), the main component of Silymarin (SM), is a natural substance
obtained from the seeds of the milk thistle. SM contains up to 70% of SB as two isoforms: A …

Atherosclerotic plaque rupture followed by luminal thrombosis is recognized as the main
cause of acute cardiovascular events, especially in patients with diabetes. Although …

Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common
regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma …

Altered metabolism of glucose, lipid and glutamine is a prominent hallmark of cancer cells.
Currently, cell heterogeneity is believed to be the main cause of poor prognosis of …

Metabolic alterations are critical events in cancers, which often contribute to tumor
pathophysiology. While aerobic glycolysis is a known characteristic of cancer-related …