Abstract Aims Reactive astrocytes in Alzheimer's disease (AD) have traditionally been
demonstrated by increased glial fibrillary acidic protein (GFAP) immunoreactivity; however …

Alzheimer's disease (AD) is characterized by extensive neurodegeneration and
inflammation in selective brain areas, linked to severely disabling cognitive deficits. Before …

Many patients with sporadic Alzheimer's disease (AD) suffer from memory impairment,
anxiety-and depression. The systemic utility of N-Methyl-d-Aspartate (NMDA) receptor …

Affective disorders including depression and anxiety are among the most prevalent
behavioral abnormalities in patients with Alzheimer's disease (AD), which affect the quality …

Astrocytes play an important role in the central nervous system (CNS). Ion channels in these
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …

Astrocytes are the main cell type responsible for the regulation of brain homeostasis,
including the maintenance of ion gradients and neurotransmitter clearance. These …

Background Identifying effective strategies to prevent memory loss in AD has eluded
researchers to date, and likely reflects insufficient understanding of early pathogenic …

ATP-sensitive potassium channels (K ATP channels), a group of vital channels that link the
electrical activity of the cell membrane with cell metabolism, were discovered on the …

Autophagy has been reported to play a dual" double-edged sword" role in the occurrence
and development of Alzheimer's disease (AD). To assess the relationship between AD and …

Alzheimer's disease (AD) is the most common form of dementia. Despite many years of
intense research, there is currently still no effective treatment. Multiple cell types contribute to …