Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Abstract Purpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy
for which treatment options remain suboptimal. It is clear that a greater understanding of the …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …

Macroautophagy, usually referred to as autophagy, is a degradative pathway wherein
cytoplasmatic components such as aggregated/misfolded proteins and organelles are …

Making decisions on how best to treat cancer patients requires the integration of different
data sets, including genomic profiles, tumour histopathology, radiological images, proteomic …

The bone marrow microenvironment is physiologically hypoxic with areas being as low as
1% O2, eg the stem cell niche. Acute myeloid leukaemia (AML) blasts misuse these bone …

Advances in technology that have transpired over the past 2 decades have enabled the
analysis of cancer samples for genomic alterations to understand their biologic function and …

Acute myeloid leukaemia (AML) is the most common adult acute leukaemia with the lowest
survival rate. It is characterised by a build‐up of immature myeloid cells anchored in the …

Being overweight or obese is associated with an increased risk of developing leukemia and
relapse, 1, 2 suggesting that adipose tissue plays an important role in this disease. It has …

In patients with acute myeloid leukemia (AML), 10% to 30% with the normal karyotype
express mutations in regulators of DNA methylation, such as TET2 or DNMT3A, in …