Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence
globally. It is well established that insulin resistance (IR) and a progressive decline in …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

There is now an impressive body of literature implicating insulin and insulin signaling in
successful aging and longevity. New information from in vivo and in vitro studies concerning …

Brown adipose tissue (BAT) has been also considered as the main thermogenic organ
responsible of maintenance body temperature through heat production. However, a new …

Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis
producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is …

Adiponectin, an insulin-sensitizing hormone, and resistin, known to promote insulin
resistance, constitute a potential link between obesity and type 2 diabetes. In addition …

Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and
atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including …

The ability of the brain to directly control glucose levels in the blood independently of its
effects on food intake and body weight has been known ever since 1854 when Claude …

A sedentary lifestyle is now known as a critical risk factor for accelerated aging-related
neurodegenerative disorders. In contract, having regular physical exercise has opposite …