Emerging mechanisms of cardiovascular protection for the omega-3 fatty acid eicosapentaenoic acid

RP Mason, P Libby, DL Bhatt - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Patients with well-controlled LDL (low-density lipoprotein) levels still have residual
cardiovascular risk associated with elevated triglycerides. Epidemiological studies have …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - ASPET
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Role of omega-3 fatty acids in cardiovascular disease: the debate continues

SCR Sherratt, P Libby, MJ Budoff, DL Bhatt… - Current atherosclerosis …, 2023 - Springer
Abstract Purpose of Review The omega-3 fatty acids (n3-FAs), eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA), have recently undergone testing for their ability to reduce …

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

SC Dyall - Frontiers in aging neuroscience, 2015 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and
represent a potential treatment for a variety of neurodegenerative and neurological …

How does high DHA fish oil affect health? A systematic review of evidence

S Ghasemi Fard, F Wang, AJ Sinclair… - Critical reviews in …, 2019 - Taylor & Francis
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content,
have attracted much scientific attention in the last four decades. Fish oils that contain higher …

New insights into mechanisms of action for omega-3 fatty acids in atherothrombotic cardiovascular disease

R Preston Mason - Current atherosclerosis reports, 2019 - Springer
Abstract Purpose of Review Treatment of hypercholesterolemia with statins results in
significant reductions in cardiovascular risk; however, individuals with well-controlled low …

Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease

JJ Liu, P Green, JJ Mann, SI Rapoport, ME Sublette - Brain research, 2015 - Elsevier
Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

Omega-3 fatty acids and skeletal muscle health

S Jeromson, IJ Gallagher, SDR Galloway, DL Hamilton - Marine drugs, 2015 - mdpi.com
Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …

A novel anti-inflammatory role of omega-3 PUFAs in prevention and treatment of atherosclerosis and vascular cognitive impairment and dementia

M Simonetto, M Infante, RL Sacco, T Rundek… - Nutrients, 2019 - mdpi.com
Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to
vascular diseases, such as stroke and myocardial infarction. The relationship between …

Polyunsaturated lipids regulate membrane domain stability by tuning membrane order

KR Levental, JH Lorent, X Lin, AD Skinkle, MA Surma… - Biophysical journal, 2016 - cell.com
The plasma membrane (PM) serves as the functional interface between a cell and its
environment, hosting extracellular signal transduction and nutrient transport among a variety …