Stem cell therapies for spinal cord injury

V Sahni, JA Kessler - Nature Reviews Neurology, 2010 - nature.com
Stem cell therapy is a potential treatment for spinal cord injury (SCI), and a variety of different
stem cell types have been evaluated in animal models and humans with SCI. No consensus …

Phase 1 safety trial of autologous human schwann cell transplantation in chronic spinal cord injury

KL Gant, JD Guest, AE Palermo, A Vedantam… - Journal of …, 2022 - liebertpub.com
A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility
and safety of autologous human Schwann cell (ahSC) transplantation accompanied by …

Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury

D Wang, RM Ichiyama, R Zhao… - Journal of …, 2011 - Soc Neuroscience
Chondroitinase ABC (ChABC) in combination with rehabilitation has been shown to promote
functional recovery in acute spinal cord injury. For clinical use, the optimal treatment window …

Clinical safety and primary efficacy of bone marrow mesenchymal cell transplantation in subacute spinal cord injured patients

S Karamouzian, SN Nematollahi-Mahani… - Clinical neurology and …, 2012 - Elsevier
BACKGROUND: In recent years, some studies were conducted to evaluate the effects of
stem cells from different sources on patients with spinal cord injury (SCI). This study was …

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

A Blesch, MH Tuszynski - Trends in neurosciences, 2009 - cell.com
Over the past three decades, multiple mechanisms limiting central nervous system
regeneration have been identified. Here, we address plasticity arising from spared systems …

Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury: A review

GWJ Hawryluk, J Rowland, BK Kwon, MG Fehlings - Neurosurgical focus, 2008 - thejns.org
Over the past 2 decades, advances in understanding the pathophysiology of spinal cord
injury (SCI) have stimulated the recent emergence of several therapeutic strategies that are …

Outcome measures in spinal cord injury: recent assessments and recommendations for future directions

MS Alexander, KD Anderson, F Biering-Sorensen… - Spinal cord, 2009 - nature.com
Study design: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is
a broad-based international consortium of scientists and clinical researchers representing …

Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury

JD Steeves, JK Kramer, JW Fawcett, J Cragg… - Spinal cord, 2011 - nature.com
Study design: Retrospective, longitudinal analysis of motor recovery data from individuals
with cervical (C4–C7) sensorimotor complete spinal cord injury (SCI) according to the …

Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: an interim report on safety considerations and possible …

H Saberi, P Moshayedi, HR Aghayan, B Arjmand… - Neuroscience …, 2008 - Elsevier
Several experimental studies have introduced Schwann cell transplantation as a means of
recovery in animal models of spinal cord injury (SCI). The reported promising results …

The effects of the timing of spinal surgery after traumatic spinal cord injury: a systematic review and meta-analysis

JJ van Middendorp, AJF Hosman… - Journal of neurotrauma, 2013 - liebertpub.com
The debate over the effects of the timing of surgical spinal decompression after traumatic
spinal cord injury (tSCI) has remained unresolved for over a century. The aim of the current …