De novo mutations in GNAO1, the gene encoding the major neuronal G protein Gαo, cause
a spectrum of pediatric encephalopathies with seizures, motor dysfunction, and …

GNAO1-related disorder encompasses a broad phenotypic continuum that includes
hyperkinetic movement disorders and/or epilepsy and is typically associated with …

GNAO1 mutated in pediatric encephalopathies encodes the major neuronal G-protein G
alpha o. Of> 40 pathogenic mutations, most are single amino acid substitutions spreading …

Background Patients carrying pathogenic variants in GNAO1 present a phenotypic spectrum
ranging from severe early‐onset epileptic encephalopathy and developmental delay to mild …

[9] Di Rocco M, Galosi S, Lanza E, Tosato F, Caprini D, Folli V, et al. Caenorhabditis elegans
provides an efficient drug screening platform for GNAO1-related disorders and highlights the …

De novo mutations in GNAO1, the gene encoding the major neuronal G protein Gαo, cause
a spectrum of pediatric encephalopathies with seizures, motor dysfunction, and …

De novo mutations in GNAO1–the gene encoding the major neuronal G-protein Gαo–cause
pediatric encephalopathies largely refractory to available therapies. Zn2+ emerged to …

De novo mutations in GNAO1–the gene encoding the major neuronal G-protein Gαo–cause
pediatric encephalopathies largely refractory to available therapies. Zn 2+ emerged to …

GNAO1-related disorder encompasses a broad phenotypic continuum that includes
hyperkinetic movement disorders and/or epilepsy and is typically associated with …

SUMMARY GNAO1-related neurodevelopmental disorders are caused by mutations in the
GNAO1 gene encoding the major neuronal G protein, Gαo. GNAO1 encephalopathies …