A review on camptothecin analogs with promising cytotoxic profile
Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline
type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic …
type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic …
Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives
G Rodriguez-Berna, MJD Cabañas… - ACS Medicinal …, 2013 - ACS Publications
Despite that 9-substituted camptothecins are promising candidates in cancer therapy, the
limited accessibility to this position has reduced the studies of these derivatives to a few …
limited accessibility to this position has reduced the studies of these derivatives to a few …
Cytotoxicity and Topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38
Q Li, X Deng, Y Zu, H Lv, L Su, L Yao, Y Zhang… - European journal of …, 2010 - Elsevier
A series of 10-position substituted nitrogenous heterocyclic aromatic group derivatives of SN-
38 were prepared. Most of these compounds possessed lower cytotoxicities than CPT …
38 were prepared. Most of these compounds possessed lower cytotoxicities than CPT …
New generation of camptothecin derivatives spontaneously alkylating DNA
B Naumczuk, K Wiktorska, K Lubelska… - New Journal of …, 2016 - pubs.rsc.org
9-Aminomethyl derivatives of 7-ethyl-10-hydroxycamptothecin were synthesized. Interaction
with a natural DNA octamer was checked using 1H NMR, PFGSE NMR and MALDI-TOF …
with a natural DNA octamer was checked using 1H NMR, PFGSE NMR and MALDI-TOF …
Synthesis of Camptothecin-10-O-glucoside Using an Engineered Oleandomycin Glucosyltransferase
X Zhu, Q Ye, C Wen, L Chen, G Liang, T Zeng… - Chemical Research in …, 2018 - Springer
Oleandomycin glycosyltransferase variant P67T/S132F/A242V (ASP) was used to convert
10-hydroxy-camptothecin into camptothecin-10-O-glucoside, which was confirmed by …
10-hydroxy-camptothecin into camptothecin-10-O-glucoside, which was confirmed by …
[图书][B] Enzymatic routes to generic building blocks leading to chiral tertiary alcohols
AM Cortijos - 2012 - search.proquest.com
Tertiary alcohols are a common functional group in many natural products, pharmaceuticals
and agrochemicals. The ability to produce highly enantiomerically pure tertiary alcohols is …
and agrochemicals. The ability to produce highly enantiomerically pure tertiary alcohols is …