Integrative regulation of human brain blood flow

CK Willie, YC Tzeng, JA Fisher… - The Journal of …, 2014 - Wiley Online Library
Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Pathophysiology of sleep apnea

JA Dempsey, SC Veasey, BJ Morgan… - Physiological …, 2010 - journals.physiology.org
Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

Regional brain blood flow in man during acute changes in arterial blood gases

CK Willie, DB Macleod, AD Shaw… - The Journal of …, 2012 - Wiley Online Library
Key points• The partial pressures of arterial carbon dioxide () and oxygen () has a marked
influence on brain blood flow.• It is unclear if the larger brain arteries are also sensitive to …

Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation

PN Ainslie, J Duffin - American Journal of Physiology …, 2009 - journals.physiology.org
Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery

J Hirsch, G DePalma, TT Tsai, LP Sands… - British journal of …, 2015 - academic.oup.com
Introduction Postoperative delirium is common in older patients. Despite its prognostic
significance, the pathophysiology is incompletely understood. Although many risk factors …

Regulation of the cerebral circulation by arterial carbon dioxide

RL Hoiland, JA Fisher, PN Ainslie - Comprehensive physiology, 2011 - Wiley Online Library
Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Cerebrovascular consequences of obstructive sleep apnea

DJ Durgan, RM Bryan Jr - Journal of the American Heart …, 2012 - Am Heart Assoc
Obstructive sleep apnea (OSA) is defined by interrupted breathing during sleep due to
airway obstruction with an ongoing respiratory effort. In adults, OSA most commonly is …

Physiology of cerebral venous blood flow: from experimental data in animals to normal function in humans

B Schaller - Brain research reviews, 2004 - Elsevier
In contrast to the cerebroarterial system, the cerebrovenous system is not well examined and
only partly understood. The cerebrovenous system represents a complex three-dimensional …

[PDF][PDF] Cerebrovascular reactivity impairment after sport-induced concussion

TK Len, JP Neary, GJG Asmundson… - Medicine & Science in …, 2011 - uregina.ca
ABSTRACT LEN, TK, JP NEARY, GJG ASMUNDSON, DG GOODMAN, B. BJORNSON, and
YN BHAMBHANI. Cerebrovascular Reactivity Impairment after Sport-Induced Concussion …

The ventilatory responsiveness to CO2 below eupnoea as a determinant of ventilatory stability in sleep

JA Dempsey, CA Smith, T Przybylowski… - The Journal of …, 2004 - Wiley Online Library
Sleep unmasks a highly sensitive hypocapnia‐induced apnoeic threshold, whereby apnoea
is initiated by small transient reductions in arterial CO2 pressure (PaCO2) below eupnoea …